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Evidence is increasing that most addiction without exception is related to difficulties with the brain's reward center, specially the mesolimbic system. This the main problem regulates reward responses in establishing food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both once they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err assisting caution and allow FDA do its job and demand some study be done so that the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on his or her medications. Researchers found out that participants taking this drug for the year, lost excess weight within 4 weeks and have kept the body weight off through the 56 weeks with the study. Contrave is really a combination with the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which can make them more effective and safer. Combo-pilling could be the newest fad or also the newest in the future under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular could be the fact that at the time of right now there are no long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise hypertension and heartrate, and mustn't be used in people with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and heart rate and must not used in patients with uncontrolled high blood pressure, and also by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. An independent report published by Gant Daily in April also stated that naltrexone also works best for kleptomaniacs and gambling addicts, too. Citing research from your University of Minnesota School of Medicine, Gant Daily reported that this drug creates kleptomaniacs and chronic gamblers just as with alcohol and opioid addicts'by blocking the consequences of endorphins, that your brain releases when experiencing craving or compulsions.